Green Synthesis of Spirooxindoles via Lipase-Catalyzed One-Pot Tandem Reaction in Aqueous Media

The development of non-natural enzymatic catalysis is important for multicomponent tandem organic transformations. However, the delicate acting environments biological enzymes still present some challenges in synthesis spirooxindole skeleton via catalysis. To address these issues, a lipase-catalyzed method was developed frameworks. Using easily available isatins, cycloketones, and malononitriles as substrates, mild reaction conditions, reasonable time, moderate to good yields (67–92%) excellent functional group tolerance were accomplished this protocol. related mechanism explanation also speculated paper.